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We read with great interest the article by Michel et al¹ on a possible association between Helicobacter pylori infection and autoimmune thrombocytopenic purpura (AITP) in adults. The authors found no cross-reactivity between platelet and H pylori antibodies and, on this basis, they excluded the evidence of an association between bacterial infection and AITP.

In their series of adults of white French origin, Michel et al detected a similar seroprevalence of H pylori in patients with AITP and in control subjects (29%). These data, although related to a small series, may be of interest, even if it is well known that seroprevalence of H pylori is greatly variable from country to country also in healthy individuals. A recent review² of the literature found that of 193 patients with AITP investigated so far in various countries, 112 (58%) were positive for H pylori infection.

Michel et al chose the serologic antibody detection . . . [Full Text of this Article]

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Immune Thrombocytopenic Purpura and Helicobacter pylori Infection
Marc Michel, Mehdi Khellaf, Bertrand Godeau, and Philippe Bierling
Arch Intern Med. 2003;163(1):120-121.
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