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In reply. In the past years, eradication of H pylori infection has been associated with the correction of thrombocytopenia in several patients with AITP, suggesting that H pylori could be implicated in AITP pathogenesis.^1-4 However, only the study by Emilia et al⁴ was based on a large series of patients, and, more recently, another group failed to demonstrate a significant improvement in platelet counts after H pylori eradication in 56 patients with chronic AITP.⁵ Using a different approach, we performed a case-control study and found no evidence for an association between H pylori carriage or past infection and AITP.⁶ The great variability of H pylori seroprevalence between countries⁶ raised by Morselli et al cannot be a source of bias in our study since AITP cases and controls were of the same ethnic and geographic origin. Nethertheless, as we have clearly discussed in our article, we did not exclude on this . . . [Full Text of this Article]

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Immune Thrombocytopenic Purpura and Helicobacter pylori Infection
Monica Morselli, Leonardo Potenza, Mario Luppi, Giuseppe Torelli, and Giovanni Emilia
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