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Arch Intern Med. 2003;163:1371-1373.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Eosinophils were first described in 1879 by Paul Ehrlich, based on their staining behavior. Eosinophils are a subpopulation of leukocytes, originating in the bone marrow from a CD34⁺ precursor. They circulate in peripheral blood, where they represent 2% to 3% of total white cells, and have a half-life of approximately 8 to 18 hours. Nevertheless, once recruited in peripheral tissues by specific cytokines, eosinophils can survive for days or weeks as resident cells. Eosinophils possess a powerful enzymatic machinery (eosinophil-derived neurotoxin, eosinophil cationic protein, and major basic protein) not shared with other types of granulocytes.¹

Since their discovery, eosinophils have raised a remarkable interest because their increase in peripheral blood was found to be associated with specific groups of diseases, such as allergic disorders and parasitic infections. For decades they were considered as bystander cells in such diseases; presently, thanks to the new diagnostic and laboratory techniques, its proinflammatory role . . . [Full Text of this Article]

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