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We are pleased that studies by Schwartzman et al confirm our initial case report describing the complete resolution of reflex sympathetic dystrophy (or CRPS) with thalidomide therapy.¹ The patient we described is doing well and continues to receive thalidomide for the treatment of myeloma at a maintenance dose of 100 mg/d. With a current follow-up of 30 months, she remains asymptomatic and has no recurrence of CRPS. We fully concur with the plan by Schwartzman et al to initiate a multicenter, randomized trial to further define and establish the role of thalidomide for this serious and disabling condition.

S. Vincent Rajkumar, MD; Rafael Fonseca, MD; Thomas E. Witzig, MD
Rochester, Minn

1. Rajkumar SV, Fonseca R, Witzig TE. Complete resolution of reflex sympathetic dystrophy with thalidomide treatment. Arch Intern Med. 2001;161:2502-2503. FREE FULL TEXT

Arch Intern Med. 2003;163:1488.

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