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It was with grave concern that I read a recent case report by Drs Gavras and Gavras in the January 27, 2003, issue of the ARCHIVES.¹ Their report described no incidents of angioedema following the use of angiotensin receptor antagonists (ARBs) in 10 patients who had previously incurred angioedema secondary to the use of angiotensin-converting enzyme (ACE) inhibitors.¹ Their case report omitted numerous findings from the literature, and as a result the authors' conclusion is dangerously misleading.

The authors stated that they were "not aware of any report about patients who developed angioedema while receiving ACE inhibition and who were subsequently treated with an ARB."¹ The fact of the matter is that numerous such cases have been reported,^2-6 the first in 1996 by Boxer.³ One of these studies reported that from a group of 13 patients known to have angioedema caused by ARB use, 3 had a history of angioedema . . . [Full Text of this Article]

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