This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on ISI (2)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We were pleased to find that our article stimulated discussion on the important topic of acetaminophen use in the alcoholic patient.¹ Our study investigated the effects of multiple maximal therapeutic dosing of acetaminophen in alcoholic patients in a controlled and randomized manner. The study was powered to detect very small differences in aspartate aminotransferase and alanine aminotransferase levels: no statistical difference was found between the acetaminophen and placebo groups at any time point.

Since acetaminophen is used by about 45 million people in the United States each week,² it is striking that so few cases of alleged acetaminophen hepatotoxicity associated with therapeutic doses in alcoholic patients have been reported over the past 40 years. The few reports published have serious omissions and conflicting data, which question their validity. Drs Soll and Sees³ also noted the weaknesses of these case reports. Although some of these patients may have ingested acetaminophen with . . . [Full Text of this Article]

RELATED ARTICLE

Effect of Maximal Daily Doses of Acetaminophen on the Liver of Alcoholic Patients: A Randomized, Double-blind, Placebo-Controlled Trial
Edwin K. Kuffner, Richard C. Dart, Gregory M. Bogdan, Robert E. Hill, Edmund Casper, and Lisa Darton
Arch Intern Med. 2001;161(18):2247-2252.
ABSTRACT | FULL TEXT