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We are grateful for the comments of Dr Hull and Mr Mah. It has repeatedly been demonstrated that site investigator–classified hemorrhage rates are lower than the rates as determined by central adjudication committees. We believe that the latter are more informative, objective, and reproducible. This is the reason why we preferred these rates in our systematic review.¹

Niklaus Strebel, MD; Martin H. Prins, MD; Harry R. Büller, MD
Amsterdam, the Netherlands

1. Strebel N, Prins M, Agnelli G, Büller HR. Preoperative or postoperative start of prophylaxis for venous thromboembolism with low-molecular-weight heparin in elective hip surgery? Arch Intern Med. 2002;162:1451-1456. FREE FULL TEXT

Arch Intern Med. 2003;163:369.

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Reporting the NAFT Major Bleeding Rates in Context: Reviewers Should Include Site Investigator–Classified Rates
Russell D. Hull and Andrew F. Mah
Arch Intern Med. 2003;163(3):369.
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