Should Routine Screening for Prostate-Specific Antigen Be Recommended?
Siam Oottamasathien, MD;
E. David Crawford, MD
Arch Intern Med. 2003;163:661-663.
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INTRODUCTION
ROUTINE SCREENING for prostate cancer remains a controversial topic. Prostate cancer is the most common cause of cancer of men in the United States and caused more than 30 000 deaths in 1999. It involves a wide pathophysiologic spectrum, from indolent disease to rapid growth and metastasis. A continued increase in frequency of prostate cancer is expected as the baby boom generation reaches the higher-risk age range for the disease. The main approaches to manage the disease include prevention, early detection (screening) and treatment, and effective treatment of advanced and/or metastatic disease. Currently, prostate-specific antigen (PSA) is the most important tumor marker for the detection, staging, and monitoring of men with prostate cancer.1
Wang and colleagues2 purified and characterized PSA in 1979, a year before it was first detected in serum.3-4 Prostate-specific antigen is a 33-kd protein produced and secreted primarily by the prostatic . . . [Full Text of this Article]
From the Division of Urology, University of Colorado Health Sciences Center, Denver. The authors have no relevant financial interest in this article.
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