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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with great interest the article by Curhan et al.¹ We have several questions regarding the conclusions of the study.

There has been a tremendous focus in the published literature regarding patient lifestyles, specifically physical activity and weight. This was also omnipresent in the lay media following the study by Ford et al² demonstrating the prevalence of metabolic syndrome in the United States alone. One of the key components of metabolic syndrome is hypertension. There is overwhelming evidence that as BMI increases, so does blood pressure. We are now beginning to elucidate some of the mechanisms of this association, correlating the effects of insulin resistance up to overt diabetes on the vasculature as well as other mediating substances that are more prevalent as BMI increases. Recently, an intriguing article was published showing a clear correlation between BMI and platelet activation, with mechanisms such as inflammation (which in turn has . . . [Full Text of this Article]

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