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NSAIDs and Hypertension—Reply
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In reply
The role of stress in the development of hypertension remains controversial.1-2 We cannot exclude the possibility raised by Glaser that increased analgesic use may be observed among individuals who experience stress. However, women take analgesics for other indications as well, such as menstrual cramps and musculoskeletal pain. Because of the known physiological effects of analgesics, it is likely that analgesics may be directly involved in the development of hypertension.
It is possible that chronic pain could lead to hypertension as proposed by Brotman, but there is insufficient information in the literature. We observed an increased risk of hypertension with use of acetaminophen or NSAIDs as infrequently as 1 to 4 days per month, which would not typically be considered a pattern of use for chronic pain. We specifically avoided claiming a causal association in our discussion. Nonetheless, acetaminophen may be a potent inhibitor of prostaglandin production in the . . . [Full Text of this Article]
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