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The recent article reporting that being overweight is a risk factor for Alzheimer disease (AD) for women¹ is consistent with the growing body of literature on the link between diet and AD.^2-7 The primary dietary risk factors are total caloric intake and saturated fat intake,^{2, 4-5,7} while cereals and fish are important risk reduction factors.^{2, 5-6} Cholesterol is also a risk factor.⁸ It has also been suggested that caloric restriction would reduce the risk of AD.³ In addition, the presence of the APOE 4 allele, the "thrifty gene," greatly increases the risk of AD for a high-risk diet.⁵

However, the lack of a finding that being overweight is a risk factor for AD for men raises the question of whether dietary or genetic factors confounded the effects of the study. It would be interesting to learn what could be determined about diet and genetics for those included in the study. Fish consumption . . . [Full Text of this Article]

William B. Grant, PhD
Newport News, Va

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