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Over-the-Counter Pain Reliever and Aspirin Use Within a Sample of Long-term Cyclooxygenase 2 Users
Arch Intern Med. 2004;164:1243-1246.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
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The Celecoxib Long-term Arthritis Safety Study (CLASS) evaluated the adverse gastrointestinal (GI) effects caused by the use of the selective cyclooxygenase 2 (COX-2) drug celecoxib and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) in patients with osteoarthritis and rheumatoid arthritis.1 The study found no significant difference in the GI ulcer complication rate (ie, bleeding, perforation, or obstruction in the GI tract) between celecoxib and nonselective NSAIDs. The authors attributed this finding to a higher-than-anticipated aspirin comedication rate of 21% among study participants, a rate almost double that of previous clinical trial experience. Since usage patterns in clinical trials and routine clinical practice often differ, the purpose of the present study was to estimate aspirin comedication rates among long-term COX-2 users. To provide a thorough description of over-the-counter (OTC) NSAID and pain reliever use, we also examine comedication with 2 other OTC NSAIDs (ie, ibuprofen and naproxen sodium) and another commonly used OTC . . . [Full Text of this Article]Methods
Results
Comment
Emily R. Cox, PhD;
Mark Frisse, MD;
Andrew Behm, PharmD;
Kathleen A. Fairman, MA
Maryland Heights, Mo
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Nonselective Nonsteroidal Antiinflammatory Drugs and Cardiovascular Risk: Are They Safe?
Waksman et al.
The Annals of Pharmacotherapy 2007;41:1163-1173.
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Hospitalization for gastrointestinal bleeding associated with non-steroidal anti-inflammatory drugs among elderly patients using low-dose aspirin: a retrospective cohort study
Rahme et al.
Rheumatology (Oxford) 2007;46:265-272.
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Arthritis Medicines and Cardiovascular Events--"House of Coxibs"
Topol
JAMA 2005;293:366-368.
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