This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Women's Health  • Women's Health, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Making Decisions in the Face of Uncertainty

Arch Intern Med. 2004;164:2308-2312.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

In 1994, we concluded in a decision analysis that women who used estrogen therapy from age 50 to 75 years would improve their quality of life.¹ Almost 10 years later, we have new evidence on the risk and protective factors associated with hormone therapy (HT) from 4 randomized controlled trials and a more sophisticated decision model presented in the ARCHIVES² that allows for a more complete balancing of the risks and benefits of hormone use. Despite these gains, important uncertainties remain regarding issues that are pivotal to understanding the role of HT, suggesting the critical need for more research, particularly with regard to the impact of HT on quality of life.

NEW EVIDENCE

Findings from 4 recent randomized controlled trials argue against any benefit of HT for prevention of coronary heart disease: (1) the Women’s Estrogen for Stroke Trial,³ which assessed the use of estrogen therapy alone (1 mg/d of estradiol-17. . . [Full Text of this Article]

MODELING ASSUMPTIONS

Coronary Heart Disease

Stroke

Breast Cancer

Alzheimer Disease

A NEW DECISION MODEL

PRIORITIES FOR RESEARCH

GUIDANCE PENDING FURTHER EVIDENCE

AUTHOR INFORMATION

Herbert B. Peterson, MD; Stephen B. Thacker, MD, MSc; Phaedra S. Corso, PhD; Polly A. Marchbanks, PhD; Jeffrey P. Koplan, MD, MPH

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hormone Therapy, Dilemmas, Medical Decisions.
Schulkin
J Law Med Ethics 2008;36:73-88.
 

Clinical and Basic Research Papers - February 2005 Selections
Seeman and Strewler
IBMS BoneKEy 2005;2:1-5.
FULL TEXT