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Risk Factors for Venous Thromboembolism
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In their article "Risk Factors for Venous Thromboembolism in Hospitalized Patients with Acute Medical Illness," Alikhan et al1 define their objectives as identifying independent risk factors for venous thromboembolism (VTE) in the patients included in the Prophylaxis in Medical Patients with Enoxaparin (MEDENOX) study, with a view to building an evidence-based risk assessment model for thromboprophylaxis. I do not agree that such a model could be built on their data.
The article was a reanalysis of data originally presented in the form of a prospective randomized trial of enoxaparin vs placebo for the prevention of VTE in acutely ill medical patients.2 The original study included a large number of inclusion and exclusion criteria aiming to include patients at high risk for VTE and exclude those for whom enoxaparin was less safe such as those with chronic renal failure and mild thrombocytopenia.
Whereas these criteria were legitimate in the original prospective . . . [Full Text of this Article] AUTHOR INFORMATION
Yaacov Richard Lawrence, MRCP(UK)
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Risk Factors for Venous Thromboembolism in Hospitalized Patients With Acute Medical Illness: Analysis of the MEDENOX Study
Raza Alikhan, Alexander T. Cohen, Sophie Combe, Meyer M. Samama, Louis Desjardins, Amiram Eldor, Charles Janbon, Alain Leizorovicz, Carl-Gustav Olsson, and Alexander G. G. Turpie
Arch Intern Med. 2004;164(9):963-968.
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