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We were pleased to see so much attention given to air travel–related venous thrombo-embolism (VTE) in a recent issue of the ARCHIVES.^1-3 However, the accompanying editorial misquoted a misleading study.⁴ The editorial correctly notes that 2 randomized trials^5-6 have demonstrated that compression stockings markedly reduce the incidence of deep vein thrombosis (DVT) during long-haul airplane flights. However, the editorial also cites the LONFLIT3 study,⁷ stating that these investigators randomized 200 high-risk passengers to low-molecular-weight heparin (LMWH) vs placebo and that the incidence of DVT was 4.8% in the control group vs 0% in the placebo group (P<.002). In fact, the LONFLIT3 study was underpowered and failed to demonstrate a statistically significant difference between the LMWH group and the placebo group in DVT incidence. The study enrolled 300 patients to 3 arms (100 patients each): an LMWH arm, a placebo arm, and a low-dose aspirin arm. A . . . [Full Text of this Article]

AUTHOR INFORMATION
Daniel J. Brotman, MD; Amir K. Jaffer, MD

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