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In reply

My colleagues and I thank Mascitelli and Pezzetta for their comments regarding our article and drawing our attention to the possible role of anti-inflammatory action in the alcohol-diabetes relationship. It is true that we did not mention anti-inflammatory properties as a possible mechanism. We had focused on the more well-established factors related to alcohol and diabetes. It is only in recent years that CRP has emerged as a predictor of type 2 diabetes mellitus. The authors quote references that have observed an independent relationship between CRP and diabetes. However, several studies have not shown CRP to be significantly predictive of diabetes after allowing for obesity or body fat or have only shown CRP to be predictive in women but not men.^1-3 Thus, the role inflammation may play in diabetes is still unclear. Furthermore, some studies have not observed significant relationships between total alcohol consumption and CRP.^4-5 We have . . . [Full Text of this Article]

S. Goya Wannamethee, PhD
London, England

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