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A Review of Potentially Dangerous Medications

Celene M. Amabile, PharmD; Anne P. Spencer, PharmD, BCPS

Arch Intern Med. 2004;164:709-720.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Heart failure (HF) is a significant health problem in the United States, with a prevalence of 5 million patients and 500 000 new diagnoses each year.¹ Heart failure is also a significant health care–dollar expenditure, with 5.4% of the health care budget contributing to its treatment.¹ Furthermore, it is a disease of the elderly, affecting 6% to 10% of those older than 65 years.² Since the elderly with concomitant disease states are highly affected, polypharmacy may be more problematic in this subpopulation.

This review is designed to assist clinicians to provide the safest pharmacotherapy for patients with HF. The information contained will summarize data published concerning medications used to treat concomitant diseases in patients with HF. In some instances, these medications may exacerbate heart failure symptoms, may be contraindicated in HF because of heightened adverse effects, or may lead to cardiac abnormalities . . . [Full Text of this Article]

ANTI-INFLAMMATORY MEDICATIONS

Corticosteroids

Nonsteroidal Anti-inflammatory Drugs

CARDIOVASCULAR MEDICATIONS

Antiarrhythmic Medications

Antihypertensive Medications

DIABETES MEDICATIONS

Metformin

Thiazolidinediones

HEMATOLOGIC MEDICATIONS

Anagrelide

Cilostazol

NEUROLOGIC AND PSYCHIATRIC MEDICATIONS

Amphetamines

Carbamazepine

Clozapine

Ergot Alkaloids

Pergolide

Tricyclic Antidepressants

MISCELLANEOUS MEDICATIONS

₂-Agonists

Herbal Medications

Itraconazole

CONCLUSIONS

From the Department of Pharmacy, Medical University of South Carolina, Charleston. Dr Amabile is now with the Department of Pharmacy, Maricopa Integrated Health System, Phoenix, Ariz. The authors have no relevant financial interest in this article.

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