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I read with interest the article by Lombardi and Passalacqua¹ on eosinophilia and diseases. I agree with the authors that eosinophilia can reflect not only allergic disorders or parasitic infections, but some other potentially severe conditions, which should also be taken into account as well when making a differential diagnosis in the presence of peripheral eosinophilia.

Among 1862 cases of gastrointestinal conditions with eosinophilia, the authors found 11 (0.5%) cases of ulcerative colitis, 5 (0.3%) cases of Crohn disease, 9 (0.5%) cases of celiac disease, and 4 (0.2%) cases of eosinophilic gastroenteritis.¹ It was surprising to see that there was not a single case of eosinophilic esophagitis (EE). Eosinophilic esophagitis is a distinct clinical syndrome and is not usually seen as a component of gastroesophageal reflux disease or as a variant of eosinophilic gastroenteritis (EG).^2-3

The diagnostic hallmark of EE is odynophagia, and the diagnosis is always dependent on histological . . . [Full Text of this Article]

Ranjit Sinharay, MRCP
Newport, Gwent, Wales

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RELATED ARTICLE

Eosinophilia and Diseases: Clinical Revision of 1862 Cases
Carlo Lombardi and Giovanni Passalacqua
Arch Intern Med. 2003;163(11):1371-1373.
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