This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (4)  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in this journal  Topic Collections  • Genetics  • Genetic Disorders  • Genetics, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Arch Intern Med. 2005;165:1815-1817.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

There is unequivocal evidence that most common illnesses, such as coronary atherosclerosis, diabetes, many cancers, obesity, and certain psychiatric diseases (eg, schizophrenia), are due to interactions between multiple genetic and environmental factors. While humans are 99.9% genetically alike, the dissimilarities of the remaining 0.1% of the human genome contribute importantly to the occurrence of human disease. These differences are composed of about 10 million common variants (present in 1% or more of alleles) and many more rare variants. Numerous reports have implicated genetic variations in the propensity toward (or resistance to) illness and the response to medical treatment. There has been considerable success in the use of genomics for mendelian disorders such as cystic fibrosis, Huntington disease, and hereditary breast-ovarian cancer (BRCA1 and BRCA2). However, many of the most common disorders lack simple mendelian inheritance and are impacted by multiple genetic events along with complex nongenetic modulators (eg, . . . [Full Text of this Article]

AUTHOR INFORMATION
Wendy S. Rubinstein, MD, PhD; Hemant K. Roy, MD

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLES

Genetic Liability to Fractures in the Elderly
Karl Michaëlsson, Håkan Melhus, Helene Ferm, Anders Ahlbom, and Nancy L. Pedersen
Arch Intern Med. 2005;165(16):1825-1830.
ABSTRACT | FULL TEXT  

Prediction of Progression to Cirrhosis by a Glutathione S-Transferase P1 Polymorphism in Subjects With Hereditary Hemochromatosis
Felix Stickel, Christoph H. Österreicher, Christian Datz, Peter Ferenci, Marco Wölfel, Wolfgang Norgauer, Michael R. Kraus, Fritz Wrba, Claus Hellerbrand, and Detlef Schuppan
Arch Intern Med. 2005;165(16):1835-1840.
ABSTRACT | FULL TEXT  

Ready for Genomic Medicine? Perspectives of Health Care Decision Makers
Paul R. Billings, Rick J. Carlson, Josh Carlson, Mary Cain, Charles Wilson, Peter Shorett, and Wendy Everett
Arch Intern Med. 2005;165(16):1917-1919.
EXTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Screening for hemochromatosis in asymptomatic subjects with or without a family history.
Powell et al.
Arch Intern Med 2006;166:294-301.
ABSTRACT | FULL TEXT