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Con

Gabriel Thabut, MD; Damien Logeart, MD

Arch Intern Med. 2005;165:2200-2203.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Although the mortality rate for those with acute PE is low, certain patients are at high risk.¹ Therefore, optimal management strategies should rely on risk stratification rather than "one-size-fits-all" treatment.² In high-risk patients, the use of aggressive treatment could be justified. Despite the lack of definitive evidence,³ massive PE associated with cardiogenic shock, given the high mortality rate, is a widely accepted indication for thrombolysis.^4-5 At the other extreme, the risks of thrombolysis are not justified in patients with an anatomically small PE that causes no elevation in RV afterload. The mortality rate for these patients is low, with most patients dying from underlying conditions rather than from PE.⁶ In a meta-analysis of 5 studies involving 1302 patients with PE treated by heparin followed by warfarin, the rate of death due to PE was only 1.5%.⁷ In such patients, the expected improvement in survival . . . [Full Text of this Article]

IS RV DYSFUNCTION AN INDEPENDENT PROGNOSTIC FACTOR IN PATIENTS WITH PE?

SHOULD THE HEMODYNAMIC BENEFITS OF TREATMENT OF PE TRANSLATE INTO CLINICAL BENEFIT?

WHAT IS THE PROVEN BENEFIT OF THROMBOLYTIC AGENTS IN PATIENTS WITH ACUTE PE AND RV DYSFUNCTION?

FUTURE DIRECTIONS

AUTHOR INFORMATION

Author Affiliations: Service de Pneumologie et Réanimation Respiratoire (Dr Thabut), and Service de Cardiologie (Dr Logeart), Hôpital Beaujon, Clichy, France.

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