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The Relation Between p70S6k Expression in Lymphocytes and the Decline of Cognitive Test Scores in Patients With Alzheimer Disease
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Memory disturbances are one of the first clinical signs detected in patients with Alzheimer disease (AD). The control of protein translation, including the kinases mTOR (mammalian target of rapamycin) and p70S6k, participates in explicit memory formation. Peripheral lymphocytes have impaired metabolism in AD.1 Our group recently reported a significant decrease of activated p70S6k expression in lymphocytes of patients with AD compared with control individuals.2 We report herein a significant correlation between activated p70S6k expression and long-term and working memory and language alterations.
Methods
Twenty-six patients with AD were enrolled (mean ± SD age, 78.6 ± 6.5 years [age range, 67-89 years]; 16 women and 10 men). Patients with AD were selected in the Departments of Neurology and Geriatrics, Poitiers University Hospital, Poitiers, France. The diagnosis was made according to the NINCDS-ADRDA (National Institute of Neurological and Communicative Diseases and Stroke/Alzheimer's Disease and Related Disorders Association) criteria. We included patients with AD with Mini-Mental State Examination . . . [Full Text of this Article]
Results
Comment
AUTHOR INFORMATION
Marc Paccalin, MD;
Stéphanie Pain-Barc, PharmD, PhD;
Claudette Pluchon, MA;
Chloé Paul, MA;
Hélène Bazin, MA;
Roger Gil, MD;
Jacques Hugon, MD, PhD
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