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A Consideration of Lipoprotein-Associated Phospholipase A₂ and C-Reactive Protein for Stroke Risk

Arch Intern Med. 2005;165:2454-2456.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Ischemic stroke is a common and often devastating condition that can cause significant disability or death. In light of the dire consequences of a completed stroke, the search for improved predictive models and new markers to identify patients at heightened risk is well justified. Such high-risk patients would be candidates for proven stroke-prevention therapies including aspirin,¹ antihypertensive medications, and HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors.²

Over the past several decades, multivariable models have been developed for prediction of coronary heart disease (CHD). A common approach to multivariate risk estimation for CHD is the Framingham Risk Score.³ This method uses readily available clinical data including the patient’s age, sex, blood pressure, blood cholesterol level, high-density lipoprotein cholesterol (HDL-C) level, smoking status, and diabetes status in a logistic regression model to estimate 10-year CHD event risk. While not perfect for CHD risk prediction, nonetheless the Framingham Risk Score markedly improves risk estimation . . . [Full Text of this Article]

AUTHOR INFORMATION
Philip Greenland, MD; LTC Patrick G. O’Malley, MC, USA

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