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In reply

Mikhail and Cope comment on our recent article, "Antiretroviral Therapy and the Prevalence and Incidence of Diabetes Mellitus in the Multicenter AIDS Cohort Study,"¹ in which we conclude that the incidence of diabetes mellitus in men with human immunodeficiency virus (HIV) infection undergoing highly active antiretroviral therapy (HAART) was 4 times greater than that found in HIV-seronegative men.

First, Mikhail and Cope state that we did not mention that our results cannot be extrapolated to women or nonwhite racial groups. Our results may or may not generalize to women and nonwhite racial groups as stated in the second paragraph of the "Comment" section. Indeed, the rate ratio of diabetes mellitus owing to HIV and HAART will generalize to these other groups if sex and race do not modify the relation between HIV and HAART and diabetes mellitus, assuming there is no measurement error. Second, Mikhail and Cope correctly . . . [Full Text of this Article]

AUTHOR INFORMATION
Todd T. Brown, MD; Stephen R. Cole, PhD; Xiuhong Li, MSc

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