This Article  • Full text  • PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Men's Health  • Prostate Disease  • Oncology  • Alert me on articles by topic

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The article by Giovannucci et al¹ points out another benefit of vigorous activity; it is associated with a slower progression of prostate cancer in men older than 65 years. The authors attribute this to possible hormonal factors. An additional mechanism might also be worth considering.

Giovannucci et al¹ controlled for diabetes. However, individuals without diabetes but with metabolic syndrome have higher than average levels of glycosylated hemoglobin A_1c.² This indicates that these patients have suboptimal glycemic control and an increased tendency to form advanced glycation end products (AGE).

Ishiguro et al³ found that the interaction between AGE and its cognate receptor (RAGE) plays a role in prostate cancer development.³ The AGE-RAGE interaction induced growth and invasion in a prostate cancer cell line (DU145).

Exercise has been found to improve glycemic control in older individuals with type 2 diabetes mellitus.⁴ It might be worth investigating whether vigorous activity improves glycemic . . . [Full Text of this Article]

AUTHOR INFORMATION
Celia M. Ross, MS

RELATED ARTICLE

A Prospective Study of Physical Activity and Incident and Fatal Prostate Cancer
Edward L. Giovannucci, Yan Liu, Michael F. Leitzmann, Meir J. Stampfer, and Walter C. Willett
Arch Intern Med. 2005;165(9):1005-1010.
ABSTRACT | FULL TEXT