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Cicardi et al¹ concluded that stopping angiotensin-converting enzyme (ACE) inhibitor use without further assessment is a successful measure in most patients who develop angioedema while taking this drug. We investigated the frequency of food allergy and sensitization to some food additives and contaminants in a group of 21 hypertensive patients referred for angioedema, urticaria, and/or itching while receiving ACE inhibitor therapy. Nine patients had angioedema, 4 patients had urticaria and/or angioedema, and 8 patients had itching. The median length of follow-up was 22.5 months (range, 4-44 months). Withdrawing the ACE inhibitor resulted in complete disappearance of symptoms in 18 patients (86%).

Prick testing with common allergens was performed for screening of type I allergies. Patients were patch tested with the European standard series and with selected food additives including sulfites (sodium bisulfite and potassium metabisulfite) and benzoates. Of the 21 patients tested, 17 (81%) exhibited at least 1 positive reaction . . . [Full Text of this Article]

AUTHOR INFORMATION
Sergio De Marchi, MD; Laura Perale, MD; Emanuela Cecchin, MD; Leonardo Alberto Sechi, MD

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