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	Since this article does not have an abstract, we have provided the first 126 words of the full text and any section headings.

Strotmeyer and colleagues¹ reported that diabetic adults are at higher fracture risk compared with nondiabetic individuals. A plausible explanation for this association, which was not considered in the study,¹ may be the consumption of thiazolidinediones in diabetic patients. These oral antidiabetic agents appear to stimulate adipocyte formation at the expense of the formation of osteoblasts.^2-3 Furthermore, the intake of thiazolidinediones by diabetic older patients has been shown to decrease bone mineral density in the femoral neck and hip.⁴ Therefore, the higher risk of fracture in patients with diabetes observed in the study by Strotmeyer and colleagues¹ might in part be related to the intake of thiazolidinedione drugs.

AUTHOR INFORMATION
Correspondence: Dr Mascitelli, Sanitary Service, Comando Brigata alpina Julia, 8 Via S Agostino, Udine 33100, Italy (lumasci@libero.it).

Luca Mascitelli, MD; Francesca Pezzetta, MD

1. Strotmeyer ES, Cauley JA, Schwartz AV, et al. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the Health, Aging, and Body Composition Study. Arch Intern Med. 2005;165:1612-1617. FREE FULL TEXT 2. Rzonca SO, Suva LJ, Gaddy D, Montague DC, Lecka-Czernick B. Bone is a target for the antidiabetic compound rosiglitazone. Endocrinology. 2004;145:401-406. FREE FULL TEXT 3. Akune T, Ohba S, Kamekura S, et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004;113:846-855. FULL TEXT | ISI | PUBMED 4. Schwartz AV, Sellmeyer DE, Feingold KR, et al. Thiazolidinedione (TZD) use and bone mineral density in older adults with diabetes [abstract]. Diabetes. 2002;51:A237-A237.

Arch Intern Med. 2006;166:126.

RELATED LETTER

Thiazolidinediones and the Risk of Nontraumatic Fractures in Patients With Diabetes: In Reply
Elsa S. Strotmeyer, Ann V. Schwartz, and Anne B. Newman
Arch Intern Med. 2006;166(9):1043.
EXTRACT | FULL TEXT  

RELATED ARTICLE

Nontraumatic Fracture Risk With Diabetes Mellitus and Impaired Fasting Glucose in Older White and Black Adults: The Health, Aging, and Body Composition Study
Elsa S. Strotmeyer, Jane A. Cauley, Ann V. Schwartz, Michael C. Nevitt, Helaine E. Resnick, Douglas C. Bauer, Frances A. Tylavsky, Nathalie de Rekeneire, Tamara B. Harris, and Anne B. Newman
Arch Intern Med. 2005;165(14):1612-1617.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Thiazolidinediones and the risk of nontraumatic fractures in patients with diabetes: in reply.
Strotmeyer et al.
Arch Intern Med 2006;166:1043-1043.
FULL TEXT