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Clinical Trials Are Required to Prove the Chemopreventive Worth of Statins
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The recent article by Eliassen et al1 found no breast cancer risk reduction among statin users from the Nurses Health Study (n = 75 828). However, there is inadequate data on type of statin uselipophobic statins have been shown to have little effect on cancer growth in vitro or in vivo and should not be included in the analysis.2 Furthermore, dose-duration effects were not considered, and data were based on self-reporting.
Mortimer et al3 (n = 68 071) found a significant reduction in breast cancers among women older than 50 years, conferred by lipophilic statin use. Kochhar et al4 (n = 40 421) similarly showed a protective benefit among lipophilic statin users (relative risk = 0.49), increasing with longer duration of use (relative risk = 0.38, use >4 years).
Eliassen et al1 also found no association among statin use and histologic subtype of the tumor, contrary to findings we will present at the San Antonio Breast Cancer Symposium. Breast cancers arising in patients . . . [Full Text of this Article] AUTHOR INFORMATION
Anjali S. Kumar, MD, MPH;
Christopher C. Benz, MD;
Laura J. Esserman, MD, MBA
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