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Prevention of Hip Fracture in Elderly Women With Alzheimer Disease—Reply
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In reply
We appreciate the comment by Kanna and Roffe regarding our article.1 Metacarpal computed x-ray densitometer measurement has been validated, and its accuracy was found to be comparable with the better known but less available method of dual-energy x-ray absorptiometry. In previous studies on patients with Parkinson disease or stroke, we found second metacarpal BMD by computed x-ray densitometer measurement to correlate with risk of hip fracture.2-3 Therefore, reduced second metacarpal BMD in patients with Alzheimer disease appears to reflect a decrease throughout the appendicular skeleton. When patients were divided into 2 groups according to their Mini-Mental State Examination (MMSE) score, the incidence of a hip fracture was higher in patients with a lower MMSE score, and risedronate therapy reduced the incidence almost equally in the 2 groups with higher or lower scores. Although we did not assess the level of physical exercise of the patients, their mental state . . . [Full Text of this Article]
AUTHOR INFORMATION
Yoshihiro Sato, MD;
Tomohiro Kanoko, PhD;
Kei Satoh, MD;
Jun Iwamoto, MD
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Prevention of Hip Fracture in Elderly Women With Alzheimer Disease
Balavenkatesh Kanna and Estrella Roffe
Arch Intern Med. 2006;166(10):1144-1145.
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The Prevention of Hip Fracture With Risedronate and Ergocalciferol Plus Calcium Supplementation in Elderly Women With Alzheimer Disease: A Randomized Controlled Trial
Yoshihiro Sato, Tomohiro Kanoko, Kei Satoh, and Jun Iwamoto
Arch Intern Med. 2005;165(15):1737-1742.
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