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In the article by Najarian et al,¹ the authors evaluated the age-adjusted risk of stroke and population-attributable risk associated with either metabolic syndrome or type 2 diabetes mellitus in a cohort of 2097 adult subjects. Metabolic syndrome was more prevalent than type 2 diabetes mellitus in that study population. In subjects without type 2 diabetes mellitus, metabolic syndrome was an independent risk factor for stroke.

Our comments are focused on the possible role of obstructive sleep apnea (OSA) as a potential factor contributing to the reported incidence of stroke in adult patients with either metabolic syndrome or type 2 diabetes mellitus. Obstructive sleep apnea is characterized by intermittent episodes of partial or complete obstruction of the upper airway during sleep and is usually associated with snoring and daytime sleepiness. It has been estimated that this sleep-related disordered breathing affects 17% to 24% of North Americans adults, and it is associated . . . [Full Text of this Article]

AUTHOR INFORMATION
Miguel A. Arias, MD, PhD; Alberto Alonso-Fernández, MD, PhD; Francisco García-Río, MD, PhD

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