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Lakoski et al¹ recently reported on data from the Coronary Artery Risk Development in Young Adults (CARDIA) Study regarding the association between C-reactive protein (CRP) concentration and incidence of hypertension. The association reported in crude analysis was no longer significant after adjusting for body mass index (BMI) (calculated as weight in kilograms divided by the square of height in meters). In fact, we believe that it was an expected finding because CRP concentration likely reflects obesity. Recent new insights into the relation between obesity and inflammatory activation show that obese individuals have larger adipocytes and consequently a larger amount of macrophages present.² Within a representative sample of Portuguese adults, in subjects with a CRP concentration of 1 mg/dL or less and no hypertension at baseline (n = 476) high-sensitivity CRP was associated with increasing BMI, both in men (Spearman correlation, 0.34; P<.001) and women (Spearman correlation, 0.34; P<.001), and the . . . [Full Text of this Article]

AUTHOR INFORMATION
Ana Azevedo, MD; Henrique Barros, MD, PhD

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