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We read with great interest the recent article by Zisman et al¹ reporting on the association between age at diagnosis of CRC and use of alcohol and tobacco. The finding that current smoking was associated with an earlier age at diagnosis of approximately 5 years is noteworthy. Equally startling was the finding that earlier age at diagnosis was associated with drinking (5.2 years earlier) and an even earlier age at diagnosis for those currently smoking and drinking (7.8 years younger). The effect of smoking was associated with a younger age at diagnosis among both sexes, but its effect was even greater in women.

These results are intriguing from both a clinical perspective in terms of screening, as well as from an etiologic perspective. It would be interesting to see if this same association held true for other sites of cancer. Zisman et al¹ mention that this finding did not hold . . . [Full Text of this Article]

AUTHOR INFORMATION
Arthur Michael Michalek, PhD; K. Michael Cummings, PhD

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