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Prolonged Ventricular Repolarization in Hypertension: Is It Heart Rate?—Reply
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In reply
We thank Funck-Brentano and Charbit for their comments on our study,1 in which we found that prolonged QTc is a risk factor for coronary events and cardiovascular mortality in uncomplicated hypertensive subjects. Given that the Bazett correction formula tends to overcorrect QT interval,1 Funck-Brentano and Charbit propose that heart rate, rather than QTc, might be associated with cardiovascular outcome in our study. This is an interesting and potentially important hypothesis. However, we had previously reported in the same population with a shorter follow-up that heart rate had no significant association with cardiovascular morbidity and mortality over the next few years.2 We rechecked this hypothesis in the present database by including heart rate as an additional explanatory variable for coronary events, and again we found that it did not predict coronary events (P = .36 in the Cox model).
We also tested the prognostic value of alternative formulas for . . . [Full Text of this Article]
AUTHOR INFORMATION
Giuseppe Schillaci, MD;
Matteo Pirro, MD;
Tiziana Ronti, MD;
Fabio Gemelli, MD;
Giacomo Pucci, MD;
Salvatore Innocente, MD;
Elmo Mannarino, MD
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Prolonged Ventricular Repolarization in Hypertension: Is It Heart Rate?
Christian Funck-Brentano and Beny Charbit
Arch Intern Med. 2006;166(19):2157.
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Prognostic Impact of Prolonged Ventricular Repolarization in Hypertension
Giuseppe Schillaci, Matteo Pirro, Tiziana Ronti, Fabio Gemelli, Giacomo Pucci, Salvatore Innocente, Carlo Porcellati, and Elmo Mannarino
Arch Intern Med. 2006;166(8):909-913.
ABSTRACT
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