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In reply

My colleagues and I appreciate the comments of Reaven and McLaughlin regarding our article.¹ We were aware of an earlier publication by McLaughlin and colleagues² in which they found that TG and the TG/HDL-C ratio were excellent markers of insulin resistance in individuals with a body mass index (calculated as weight in kilograms divided by the square of height in meters) of greater than 25. The ethnic composition of 258 individuals in their study was 87% white, 1% African American, and 12% other ethnicities. Thus, we thought it was important to apply the criteria that they found to work well in the diagnosis of insulin resistance in whites to a larger group of African Americans. Of note, the discussion by McLaughlin et al² recommends further testing in African Americans.

Our data indicate that the relationship between insulin resistance and TG level is different in African Americans than in . . . [Full Text of this Article]

AUTHOR INFORMATION
Anne E. Sumner, MD