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We thank Kshirsagar and Colindres for their comments on our article.¹ Because we analyzed the percentage change in serum creatinine concentration between visits 1 and 2 of the ARIC study and because creatinine assays for the first 2 ARIC visits were performed at the same laboratory (University of Minnesota) with very similar calibration, there was no need to adjust to the Cleveland Clinic laboratory. We did not use the Modification of Diet in Renal Disease equation and did not classify glomerular filtration rate estimates.^2-3 We therefore see no possibility of misclassification bias.

These authors refer to a race interaction in their cross-sectional analysis of an estimated glomerular filtration rate below 90 mL/min per 1.73m² and low ABI among ARIC participants. In our study, the odds ratio for the longitudinal association of low ABI with a 50% or greater increase in creatinine concentration was actually higher among white (3.01; . . . [Full Text of this Article]

AUTHOR INFORMATION
Ann M. O’Hare, MA, MD; Rudolph A. Rodriguez, MD; Peter Bacchetti, PhD

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