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I read with interest the article in which Qiu et al¹ report that heart failure was associated with an increased risk of dementia and Alzheimer disease in a cohort of individuals 75 years or older. This relationship was offset in those receiving antihypertensive medication, 82.9% of whom were given diuretics.¹ Even though the study was well designed and the results were analyzed appropriately, these findings require confirmation, since they are novel.

The authors speculate on the possible mechanisms involved in the risk effect of heart failure on dementia and conjecture that this relationship might be attenuated by antihypertensive therapy, mainly with diuretics.¹ I would like to consider a question that connotes an expansion of the scope of research on heart failure, that is, Alzheimer disease and the use of diuretics thereof. Diuretics reduce the renal excretion and thereby raise the serum level of uric acid, and sodium intake curtailment exerts . . . [Full Text of this Article]

AUTHOR INFORMATION
Ariel J. Reyes, MD

RELATED ARTICLE

Heart Failure and Risk of Dementia and Alzheimer Disease: A Population-Based Cohort Study
Chengxuan Qiu, Bengt Winblad, Alessandra Marengoni, Inga Klarin, Johan Fastbom, and Laura Fratiglioni
Arch Intern Med. 2006;166(9):1003-1008.
ABSTRACT | FULL TEXT