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COMMENTS & OPINIONS
Clopidogrel in Patients With Acute Coronary Syndromes: Learning From Clinical Practice
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Tricoci et al1 examined over 60 000 patients with high-risk nonST-segment elevation acute coronary syndrome (NSTE ACS) in the CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA [American College of Cardiology/American Heart Association] Guidelines) Quality Improvement Initiative. They found that only slightly over half received clopidogrel at discharge and the majority who did not undergo catheterization did not receive clopidogrel. The patterns and trends for receiving clopidogrel were similar for patients who received care by cardiologists or noncardiologists, a fact that might seem surprising in light of published guidelines.2
Perhaps this is not as surprising as it first appears. Guideline recommendations regarding dual antiplatelet therapy for patients with NSTE ACS were driven largely by the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) trial,3 in which the primary outcome measure of cardiovascular death, nonfatal myocardial infarction, and stroke was significantly . . . [Full Text of this Article] AUTHOR INFORMATION
Roy C. Ziegelstein, MD
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Clopidogrel to Treat Patients With NonST-Segment Elevation Acute Coronary Syndromes After Hospital Discharge
Pierluigi Tricoci, Matthew T. Roe, Jyotsna Mulgund, L. Kristin Newby, Sidney C. Smith, Jr, Charles V. Pollack, Jr, Dan J. Fintel, Christopher P. Cannon, Deepak L. Bhatt, W. Brian Gibler, E. Magnus Ohman, Eric D. Peterson, and Robert A. Harrington
Arch Intern Med. 2006;166(7):806-811.
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