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Arch Intern Med. 2006;166:715-716.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

This issue of the ARCHIVES includes a focus on fibrates, with the publication of 2 articles, one an 18-year mortality follow-up report from the Helsinki Heart Study (HHS) and the other, a report on the role of bezafibrate in preventing the progression of insulin resistance.^1-2 In an era dominated by statins (is there anything they cannot do?), it is timely to ask whatever became of the fibrates and what role, if any, they have in a statin world.

It all started with fibrates over 30 years ago. Clofibrate was the first agent to be tested in clinical trials in the 1970s designed to evaluate the effect of lowering cholesterol level on cardiac outcomes. Unfortunately, one of these trials (the World Health Organization's Cooperative Primary Prevention Trial) showed an excess risk of cancer and all-cause mortality among those receiving active treatment, and clofibrate has since been removed from the market. . . . [Full Text of this Article]

AUTHOR INFORMATION
Hanna E. Bloomfield, MD, MPH

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