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In their letter published in the January 9, 2006, issue of the ARCHIVES, Mascitelli and Pezzetta¹ state that thiazolidinedione use has been shown to decrease hip and femoral neck bone mineral density (BMD)² and suggest that this is an explanation for our report that adults with type 2 diabetes mellitus are at higher fracture risk compared with adults without diabetes in the Health, Aging, and Body Composition (Health ABC) Study.³ While we agree that thiazolidinedione use may be associated with bone loss, the prevalence of thiazolidinedione use was too low to account for the increased fracture risk associated with type 2 diabetes mellitus that we reported.³ The reference that Mascitelli and Pezzetta¹ cite is also from the Health ABC Study,² and only 11 (2%) of 566 participants with diabetes in our report used a thiazolidinedione at the start of the study in 1997-1998. In the first 4 years . . . [Full Text of this Article]

AUTHOR INFORMATION
Elsa S. Strotmeyer, PhD, MPH; Ann V. Schwartz, PhD; Anne B. Newman, MD, MPH

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