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Klaus Eichler, MD, MPH; Milo A. Puhan, MD, PhD; Lucas M. Bachmann, MD, PhD

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Guidance on statin provision in patients without cardiovascular disease is of great practical importance. In recent years, several publications emerged showing conflicting results. The systematic review by Thavendiranathan et al¹ is timely and covers a relevant issue but not without limitations. We have 3 observations.

First, this review enrolled moderate- and high-risk patients (average extrapolated 10-year coronary risk, 13%) despite the fact that greater than 80% of the US population who are free of cardiovascular disease do not fall into this risk category.² No direct conclusions of the effects in this large group can therefore be made. Second, it is unclear how the authors reached the conclusion that "reductions in the risk of major coronary events from statin therapy were significantly associated with greater absolute baseline coronary artery disease risk."^1(p2310) We were unable to reproduce this . . . [Full Text of this Article]

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