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COMMENTS & OPINIONS
The Role of Statins in Primary Prevention of Cardiovascular Disease—Reply
Paaladinesh Thavendiranathan, MD, MSc;
Akshay Bagai, MD;
M. Alan Brookhart, PhD;
Niteesh K. Choudhry, MD, PhD
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In reply
Eichler and colleagues offer several helpful comments about our analysis. First, we agree that our article provides limited guidance regarding low coronary risk populations, since the majority of patients in our meta-analysis were of intermediate to high coronary risk.1
Second, we are grateful to Eichler and colleagues for pointing out an error in our results. The text in the "Metaregression" subsection of the "Results" section should have read that greater reductions in the (relative) benefit in statin therapy were associated with smaller (not greater) baseline coronary artery disease risk.1(p2310) As such, our results support the forest plot that Eichler and colleagues present. Despite this, high-risk patients still derive sizable absolute benefits from therapy by virtue of their elevated baseline rate of events.
Finally, we assumed homogeneity of treatment effects for the calculation . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
The Role of Statins in Primary Prevention of Cardiovascular Disease
Klaus Eichler, Milo A. Puhan, and Lucas M. Bachmann
Arch Intern Med. 2007;167(10):1100.
EXTRACT
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RELATED ARTICLE
Primary Prevention of Cardiovascular Diseases With Statin Therapy: A Meta-analysis of Randomized Controlled Trials
Paaladinesh Thavendiranathan, Akshay Bagai, M. Alan Brookhart, and Niteesh K. Choudhry
Arch Intern Med. 2006;166(21):2307-2313.
ABSTRACT
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