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COMMENTS & OPINIONS
What If Chlorthalidone-Associated Hyperglycemia Develops?
Alan Silver, MD, MPH
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Barzilay et al1 present data and opinions supporting the contention that chlorthalidone-associated hyperglycemia is benign.2 What is the authors' opinion if it does develop? Does one ignore it, treat it and continue thiazide therapy, or stop the diuretic and change medications?
AUTHOR INFORMATION
Correspondence: Dr Silver, Department of Quality Management, North Shore–Long Island Jewish Health System, 1979 Marcus Ave, Lake Success, NY 11042 (asilver@lij.edu).
1. Barzilay JI, Davis BR, Cutler JA; et al, ALLHAT Collaborative Research Group. Fasting glucose levels and incident diabetes mellitus in older nondiabetic adults randomised to receive 3 different classes of antihypertensive treatment: a report from the Antihypertensive and Lipid-lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Arch Intern Med. 2006;166(20):2191-2201.
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2. Phillips RA. New-onset diabetes mellitus less deadly than elevated blood pressure? following the evidence in the administration of thiazide diuretics. Arch Intern Med. 2006;166(20):2174-2176.
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Arch Intern Med. 2007;167(13):1434.
RELATED LETTER
What If Chlorthalidone-Associated Hyperglycemia Develops?Reply
Joshua I. Barzilay, Jeffrey A. Cutler, Barry R. Davis, Sara L. Pressel, Paul K. Whelton, Jan Basile, Karen L. Margolis, Stephen T. Ong, Laurie S. Sadler, John Summerson, and for the ALLHAT Collaborative Research Group
Arch Intern Med. 2007;167(13):1434-1435.
EXTRACT
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RELATED ARTICLE
Fasting Glucose Levels and Incident Diabetes Mellitus in Older Nondiabetic Adults Randomized to Receive 3 Different Classes of Antihypertensive Treatment: A Report From the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
Joshua I. Barzilay, Barry R. Davis, Jeffrey A. Cutler, Sara L. Pressel, Paul K. Whelton, Jan Basile, Karen L. Margolis, Stephen T. Ong, Laurie S. Sadler, John Summerson, and for the ALLHAT Collaborative Research Group
Arch Intern Med. 2006;166(20):2191-2201.
ABSTRACT
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