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COMMENTS & OPINIONS
Folic Acid and Cognitive Function: What Is the Final Verdict?
Samar Harris, MBBS;
Harris V. K. Naina, MBBS;
Sameer Siddique, MRCP
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In their systematic review on pyridoxine hydrochloride (vitamin B6), cyanocobalamin or hydroxycobalamin (vitamin B12), and folic acid supplementation on cognitive function, Balk et al1(p21) concluded that
the evidence does not yet provide adequate evidence of an effect of vitamin B6 or B12 or folic acid supplementation, alone or in combination, on cognitive function testing in people with either normal or impaired cognitive function.
Though authors have mentioned a non–peer reviewed abstract on the benefits of folic acid supplementation on cognitive function in patients with hyperhomocysteinemia, we would like to share the recent Folic Acid and Carotid Intima-media Thickness (FACIT) trial, a double-blind, placebo-controlled study to assess the effect of folic acid on markers of atherosclerosis in men and women aged 50 to 70 years with raised plasma total homocysteine and normal serum vitamin B12 levels at screening . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
Folic Acid and Cognitive Function: What Is the Final Verdict?—Reply
Ethan M. Balk, Gowri Raman, and Irwin H. Rosenberg
Arch Intern Med. 2007;167(14):1555.
EXTRACT
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ABSTRACT
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