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COMMENTS & OPINIONS
Folic Acid and Cognitive Function: What Is the Final Verdict?—Reply
Ethan M. Balk, MD, MPH;
Gowri Raman, MD;
Irwin H. Rosenberg, MD
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In reply
With the addition of the 2 recently published randomized trials of folic acid described by Naina et al, the evidence remains inconclusive, although folic acid supplementation may benefit specific populations. Even with these trials, as we reported, "firm conclusions are not possible" and the trials "do not provide adequate evidence for a beneficial effect of supplementation on cognitive function testing in people with either normal or impaired cognitive function."1(p29)
AUTHOR INFORMATION
Correspondence: Dr Balk, Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, 750 Washington St, NEMC #63, Boston, MA 02111 (ebalk@tufts-nemc.org).
1. Balk EM, Raman G, Tatsioni A, Chung M, Lau J, Rosenberg IH. Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Arch Intern Med. 2007;167(1):21-30.
FREE FULL TEXT
Arch Intern Med. 2007;167(14):1555.
RELATED LETTER
Folic Acid and Cognitive Function: What Is the Final Verdict?
Samar Harris, Harris V. K. Naina, and Sameer Siddique
Arch Intern Med. 2007;167(14):1555.
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