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COMMENTS & OPINIONS
The Number Needed to Be Exposed: A Potential Use for Quantifying the Strength of an Individual Risk Factor Including a Protective Factor in a Cohort Study—Reply
James R. Cerhan, MD, PhD;
Aditya Bardia, MD, MPH;
Robert A. Vierkant, MS;
Celine M. Vachon, PhD
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In reply
We appreciate Cheng's interest in our study,1 and we agree that it can be very useful to use additional measures of association to quantify the impact of risk factors on breast cancer incidence. The focus of our analysis was to evaluate whether physical activity was differentially associated with breast cancer subtypes defined by estrogen and progesterone receptor status, and therefore we used the RR as our main measure of association. The advantage of the RR is that it is generally independent of the underlying baseline risk and therefore can be compared more easily across studies. This facilitates replication of findings, which is critical before assessing the impact of a risk or protective factor. However, readers are also interested in the potential public health significance of putative associations, and we also provided . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
The Number Needed to Be Exposed: A Potential Use for Quantifying the Strength of an Individual Risk Factor Including a Protective Factor in a Cohort Study
Huai yong Cheng
Arch Intern Med. 2007;167(15):1690.
EXTRACT
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RELATED ARTICLE
Recreational Physical Activity and Risk of Postmenopausal Breast Cancer Based on Hormone Receptor Status
Aditya Bardia, Lynn C. Hartmann, Celine M. Vachon, Robert A. Vierkant, Alice H. Wang, Janet E. Olson, Thomas A. Sellers, and James R. Cerhan
Arch Intern Med. 2006;166(22):2478-2483.
ABSTRACT
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