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Huai yong Cheng, MD, MPH

	Since this article does not have an abstract, we have provided the first 135 words of the full text and any section headings.

Schett and colleagues¹ found that the high-sensitivity C-reactive protein (hs-CRP) level was a significant and independent risk predictor of nontraumatic fracture in the Bruneck study. This conclusion was mainly based on the higher incidence of nontraumatic fracture and odds ratio in the highest tertile group of hs-CRP.¹ However, using the odds ratio in gauging the performance of prognostic marker has limitations.² The receiver operating characteristics curve was recommended to assess the predictor or new marker.^2-4 It would be helpful for readers to decide whether hs-CRP level could be used as a new predictor for nontraumatic fracture if the receiver operating characteristic curve of hs-CRP were analyzed and reported in their study.¹

AUTHOR INFORMATION
Correspondence: Dr Cheng, The Allen Pavilion, Columbia University Medical Center, 5141 Broadway, New York, NY 10034-1159 (hyc2105@columbia.edu).

1. Schett G, Kiechl S, Weger S; et al. High-sensitivity C-reactive protein and risk of nontraumatic fracture in the Bruneck study. Arch Intern Med. 2006;166(22):2495-2501. FREE FULL TEXT 2. Pepe MS, Janes H, Longton G; et al. Limitations of the odds ratio in gauging the performance of a diagnostic, prognostic, or screening marker. Am J Epidemiol. 2004;159(9):882-890. FREE FULL TEXT 3. de Lemos JA. The latest and greatest new biomarkers: which ones should we measure for risk prediction in our practice? Arch Intern Med. 2006;166(22):2428-2430. FREE FULL TEXT 4. Greenland P. When is a new prediction marker useful? a consideration of lipoprotein-association phospholipase A2 and C-reactive protein for stroke risk. Arch Intern Med. 2005;165(21):2454-2456. FREE FULL TEXT

Arch Intern Med. 2007;167(18):2007.

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RELATED LETTERS

The Latest and Greatest New Biomarkers: Which Ones Should We Measure for Risk Prediction in Our Practice?
James A. de Lemos
Arch Intern Med. 2006;166(22):2428-2430.
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High-Sensitivity C-Reactive Protein and Prediction of Nontraumatic Fractures—Reply
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Arch Intern Med. 2007;167(18):2007-2008.
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