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Laurent Peyrin-Biroulet, MD, PhD; Jean-Louis Guéant, MD, DSc; Xavier Roblin, MD

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We read with great interest the article by Pereira et al¹ showing an inverse association of coffee intake with risk of type 2 diabetes mellitus in a large prospective study of postmenopausal women. The protective effect of coffee against diabetes could not be attributed to caffeine because the inverse associations of coffee consumption with diabetes risk were stronger for decaffeinated coffee than for regular (caffeinated) coffee.¹ The authors concluded that other components of coffee such as antioxidants could reduce the risk of diabetes, but the question remains of why regular coffee consumption might not decrease the risk of diabetes. In this setting, it would have been interesting to investigate the contribution of the homocysteine-raising effect of caffeine to the risk of diabetes.

Indeed, a dose-response association between coffee consumption and homocysteine level was reported in several studies. In a . . . [Full Text of this Article]

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RELATED ARTICLE

Coffee Consumption and Risk of Type 2 Diabetes Mellitus: An 11-Year Prospective Study of 28 812 Postmenopausal Women
Mark A. Pereira, Emily D. Parker, and Aaron R. Folsom
Arch Intern Med. 2006;166(12):1311-1316.
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