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COMMENTS & OPINIONS
Glycemic Load and Cardiovascular Risk
Peter Clifton, MD, PhD
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McMillan-Price and colleagues1 are to be congratulated for performing a large study to examine the impact of low-glycemic-load weight loss diets. However, the conclusions do not tally with the data in the article. All diets caused fat loss, and there was no significant difference between them. The post hoc analysis of weight loss in women is not justified without first showing a significant interaction between sex and fat loss. Although the high-carbohydrate, low–glycemic index (GI) diet lowered low-density lipoprotein cholesterol (LDL-C) levels the most, the high-protein, low-GI diet lowered the high-density lipoprotein cholesterol (HDL-C) ratio the most. Thus, the conclusion that the high-carbohydrate, low-GI diet is best for lowering heart disease risk is not justified on the data presented. The results of the study in relation to LDL-C are very unusual, since striking reductions in saturated fat were reported with all the diets but elevations in . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
Glycemic Load and Cardiovascular Risk—Reply
Jennie Brand-Miller, Joanna McMillan-Price, and Peter Petocz
Arch Intern Med. 2007;167(2):206-207.
EXTRACT
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RELATED ARTICLE
Comparison of 4 Diets of Varying Glycemic Load on Weight Loss and Cardiovascular Risk Reduction in Overweight and Obese Young Adults: A Randomized Controlled Trial
Joanna McMillan-Price, Peter Petocz, Fiona Atkinson, Kathleen O’Neill, Samir Samman, Katherine Steinbeck, Ian Caterson, and Jennie Brand-Miller
Arch Intern Med. 2006;166(14):1466-1475.
ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
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Glycemic index, glycemic load, and chronic disease risk--a meta-analysis of observational studies
Barclay et al.
Am. J. Clin. Nutr. 2008;87:627-637.
ABSTRACT
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