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COMMENTS AND OPINIONS
Migraine and Heart Rate Variability—Reply
Tobias Kurth, MD, ScD;
J. Michael Gaziano, MD, MPH;
Nancy R. Cook, ScD;
Vadim Bubes, PhD;
Giancarlo Logroscino, MD, PhD;
Hans-Christoph Diener, MD, PhD;
Julie E. Buring, ScD
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In reply
We appreciate Perciaccante and colleagues adding another piece to the mechanistic puzzle in suggesting that migraine may be linked not only to brain artery and neuronal dysfunctions but also with systemic dysfunctions that have been associated with risk of CVD. In their study, patients with migraine with aura had lower heart rate variability compared with control persons without migraine. Moreover, another recent cross-sectional study provided evidence that functional properties of peripheral arteries were altered in patients with migraine compared with controls.1
Jindeel correctly raises the question whether the migraine-CVD association could be related to analgesic use. However, we believe that the use of NSAIDs or COX-2 inhibitors is an unlikely explanation of the migraine-CVD association. First, such medications are used . . . [Full Text of this Article]
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RELATED LETTER
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ABSTRACT
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