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COMMENTS & OPINIONS
Selective Serotonin Reuptake Inhibitors and Risk of Fracture in Elderly Persons
Oladipo Kukoyi, MD, MS
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The study by Richards and colleagues1 indicates an association between selective serotonin reuptake inhibitor (SSRI) use and fracture risk in elderly persons by ascertaining daily SSRI use in a cohort of patients at baseline and 5 years later and the fracture incidence in this cohort after controlling for potentially confounding variables. There are several limitations to this study. The authors are incorrect when they argue that inhaled corticosteroids have not been clearly associated with fracture. Recent data clearly demonstrate the link between inhaled corticosteroids and fracture.2 Furthermore, depression has also been linked to earlier perimenopause, another condition strongly linked to fracture risk.3 Most important, the authors fail to discuss the relationship between depression and osteoporosis that has been known for decades and did not account for it in their statistical analysis. Several studies indicate that depression is a risk factor for reduced bone mineral density and . . . [Full Text of this Article]
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RELATED ARTICLE
Effect of Selective Serotonin Reuptake Inhibitors on the Risk of Fracture
J. Brent Richards, Alexandra Papaioannou, Jonathan D. Adachi, Lawrence Joseph, Heather E. Whitson, Jerilynn C. Prior, David Goltzman, and for the Canadian Multicentre Osteoporosis Study (CaMos) Research Group
Arch Intern Med. 2007;167(2):188-194.
ABSTRACT
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