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COMMENTS & OPINIONS
A Possible Overestimation of the Effect of Aspirin
Jaapjan D. Snoep, MSc;
Olaf M. Dekkers, MD, PhD;
Jan P. Vandenbroucke, MD, PhD
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In their nested case-control study on aspirin use and mortality in women within the Nurses Health Study, Chan et al1 conclude that aspirin use is associated with a decreased mortality. The reported effect is clearly stronger than results of previous randomized controlled trials suggested. The effect of aspirin in this study may be overestimated for 2 reasons that are remediable.
The comparison between women taking aspirin and women not taking aspirin may not be straightforward for reasons other than the known difference in risk factors between these groups. Women taking aspirin regularly for preventive reasons may have a healthier lifestyle and may be more compliant users of medications, factors that are known to lead to too optimistic estimates of effects.2 It would therefore be interesting to evaluate the effect of aspirin on all-cause as well as . . . [Full Text of this Article]
AUTHOR INFORMATION
RELATED LETTER
A Possible Overestimation of the Effect of Aspirin—Reply
Andrew Chan and Charles S. Fuchs
Arch Intern Med. 2007;167(21):2373.
EXTRACT
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Arch Intern Med. 2007;167(6):562-572.
ABSTRACT
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